研究室概要
工事中！！
メンバー
教員
准教授 藤堂 景史
（Kagefumi TODO, Ph.D）
4年生
6名
3年生
5名
業績
- Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.
Satooka H, Ishigaki H, Todo K, Terada K, Agata Y, Itoh Y, Ogasawara K, Hirata T. Sci Rep. (2020) - Oligomers imaging of amyloid-β 1-42 by scanning tunneling microscopy.
Naruse N, Satooka H, Todo K, Nakanishi A, Taguchi T, Mera M Jpn J Appl Phys. (2019) - 胚中心におけるB細胞選択機構と記憶B細胞の生成
疋田正喜、藤堂景史 酵素工学ニュース (2017) - 胚中心B細胞のシグナル伝達機構
藤堂景史、疋田正喜 炎症と免疫 (2015) - クラススイッチしたB細胞における新規な負の調節因子
藤堂景史、疋田正喜 臨床免疫・アレルギー科 (2015) - Modulation of Igβ is essential for the B cell selection in germinal center.
Todo K, Koga O, Nishikawa M, Hikida M. Sci Rep. (2015) - IgG1 cytoplasmic tail is essential for cell surface expression in Igβ down-regulated cells.
Todo K, Koga O, Nishikawa M, Hikida M. Biochem Biophys Res Commun. (2014) - Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1.
Kanehiro Y*, Todo K*, Negishi M, Fukuoka J, Gan W, Hikasa T, Kaga, Takemoto M, Magari M, Li X, Manley JL, Ohmori H, Kanayama N. Proc Natl Acad Sci U S A. (2012) ( * equal contribution) - Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation.
Kajita M, Okazawa T, Ikeda M, Todo K, Magari M, Kanayama N, Ohmori H. J Biosci Bioeng. (2010) - Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire.
Magari M, Kanehiro Y, Todo K, Ikeda M, Kanayama N, Ohmori H. Biochem Biophys Res Commun. (2010) - Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line.
Kajita M, Magari M, Todo K, Kanayama N, Ohmori H. J Biosci Bioeng. (2010) - 培養B細胞を用いるin vitro抗体作製システムによる有用抗体の創製
金山直樹、藤堂景史、曲正樹、大森斉 薬学雑誌 (2009) - Enhancement of antibody production from a chicken B cell line DT40 by reducing Pax5 expression.
Magari M, Aya T, Ikeda M, Todo K, Kanayama N, Ohmori H. J Biosci Bioeng. (2009) - Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na+/H+ exchanger isoform-1 protein.
Matsushita M, Sano Y, Yokoyama S, Takai T, Inoue H, Mitsui K, Todo K, Ohmori H, Kanazawa H. Am J Physiol Cell Physiol. (2007) - Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library.
Todo K, Miyake K, Magari M, Kanayama N, Ohmori H. J Biosci Bioeng. (2006) - 変異機能のON/OFF制御可能なB細胞株を用いた抗体および変異タンパク質の作製システム
大森斉、藤堂景史、金山直樹 実験医学 (2006) - Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line.
Kanayama N, Todo K, Takahashi S, Magari M, Ohmori H. Nucleic Acids Res. (2006) - Reversible switching of immunoglobulin hypermutation machinery in a chicken B cell line.
Kanayama N, Todo K, Reth M, Ohmori H. Biochem Biophys Res Commun. (2005) - B cell selection and affinity maturation during an antibody response in the mouse with limited B cell diversity.
Kanayama N, Kimoto T, Todo K, Nishikawa Y, Hikida M, Magari M, Cascalho M, Ohmori H. J Immunol. (2002)
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